Chronic Obstructive Airway Disease
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Common and Rare Variants Genetic Association Analysis of Cigarettes per Day Among Ever-Smokers in Chronic Obstructive Pulmonary Disease Cases and Controls.
|
29767774 |
2019 |
Chronic Obstructive Airway Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In addition, the A alleles in CHRNA3 rs1051730 and CHRNA5 rs16969968 were associated with the risk for LC (OR = 1.66, P = 0.07 and OR = 1.57, P = 0.1, respectively) and for COPD (OR = 2.04, P = 0.01 and OR = 1.91, P = 0.02, respectively).
|
29993116 |
2018 |
Chronic Obstructive Airway Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We apply the Umediation package to the Genetic Epidemiology of Chronic Obstructive Pulmonary Disease (COPDGene) study to examine the role of unmeasured confounding due to population stratification on the effect of a single nucleotide polymorphism (SNP) in the CHRNA5/3/B4 locus on pulmonary function decline as mediated by cigarette smoking.
|
28724417 |
2017 |
Chronic Obstructive Airway Disease
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis.
|
28166215 |
2017 |
Chronic Obstructive Airway Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Our data suggest that gene variance in the CHRNA5-CHRNA3-CHRNB4 cluster is associated with an increased risk of death, incidence of COPD and tobacco-related cancer in smokers.
|
26689306 |
2016 |
Chronic Obstructive Airway Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Our top result was rs16969968 (P = 1.7 × 10(-14)) in CHRNA5, a locus previously associated with COPD susceptibility and nicotine dependence.
|
26771213 |
2016 |
Chronic Obstructive Airway Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Our data replicate previous result suggesting CHRNA5 as a candidate gene for COPD and rs8040868 as a risk variant for the development of COPD in the Swedish population.
|
27835950 |
2016 |
Chronic Obstructive Airway Disease
|
0.200 |
Biomarker
|
disease |
BEFREE |
Single-nucleotide polymorphisms (SNPs) in the cholinergic nicotinic receptor subunit genes on chromosome 15q25.1, including CHRNA3, CHRNB4 and CHRNA5, are well-established biomarkers of chronic obstructive pulmonary disease (COPD) and lung cancer.
|
27462996 |
2016 |
Chronic Obstructive Airway Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The rs13180 (IREB2), rs16969968 (CHRNA5) and rs1051730 (CHRNA3) were significantly associated with COPD in additive model [Padj =0.00001, odds ratio (OR)=0.64; Padj =0.0001, OR=1.41 and Padj =0.0001, OR=1.47].
|
28474623 |
2016 |
Chronic Obstructive Airway Disease
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry.
|
26634245 |
2015 |
Chronic Obstructive Airway Disease
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
IREB2 and GALC are associated with pulmonary artery enlargement in chronic obstructive pulmonary disease.
|
25101718 |
2015 |
Chronic Obstructive Airway Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Recently, variants in the hypoxia-inducible factor 1α (HIF1A), cholinergic receptor, neuronal nicotinic, alpha polypeptide-5, and iron-responsive element-binding protein 2 gene (IREB2) genes were found to be associated with COPD.
|
25565795 |
2015 |
Chronic Obstructive Airway Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Exon sequencing identifies a novel CHRNA3-CHRNA5-CHRNB4 variant that increases the risk for chronic obstructive pulmonary disease.
|
25891420 |
2015 |
Chronic Obstructive Airway Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Because the associations with lung disease remain after adjustment for self-reported smoking behaviors, it has been asserted that CHRNA5-CHRNA3-CHRNB4 variants increase COPD and lung cancer susceptibility independently of their effects on smoking.
|
25072098 |
2014 |
Chronic Obstructive Airway Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The polymorphism of CHRNA5 did not have a significant influence on the elevated risk of lung cancer and COPD.
|
21955800 |
2012 |
Chronic Obstructive Airway Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Role of CHRNA5-A3 genetic Locus variants and developing drug for chronic obstructive pulmonary disease.
|
23061658 |
2012 |
Chronic Obstructive Airway Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Method for evaluating multiple mediators: mediating effects of smoking and COPD on the association between the CHRNA5-A3 variant and lung cancer risk.
|
23077662 |
2012 |
Chronic Obstructive Airway Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Adjusting for 3309 tests (p<1.5e-5), the two SNPs which were significantly associated with COPD were located in two separate genes in a known COPD locus on chromosome 15: CHRNA5 and IREB2.
|
21949713 |
2011 |
Chronic Obstructive Airway Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Associations of CHRNA3/CHRNA5 and CYP2A6 loci with CPD and DBH with smoking cessation are also likely of importance in the smoking behaviours of patients with COPD.
|
21685187 |
2011 |
Chronic Obstructive Airway Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Several independent studies show that the chromosome 15q25.1 region, which contains the CHRNA5-CHRNA3-CHRNB4 gene cluster, harbors variants strongly associated with nicotine dependence, other smoking behaviors, lung cancer and chronic obstructive pulmonary disease.
|
20584212 |
2010 |
Chronic Obstructive Airway Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The authors applied a rigorous statistical approach, mediation analysis, to examine the mediating effect of smoking behavior and self-reported, physician-diagnosed emphysema (chronic obstructive pulmonary disease [COPD]) on the relation between the CHRNA5-A3 region genetic variant rs1051730 and the risk of lung cancer.
|
20564069 |
2010 |